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Add Impact of Testosterone on Male Health: A Systematic Review

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Given the association of elevated androgens, particularly DHT, with increased prostate cancer risk (9), the rise in DHT with exercise that occurred in our study might be of concern. This finding suggests that physiologic pathways might exist for exercise to affect DHT other than altered fat mass. Surprisingly, we did not find that DHT increases were greater among men who lost more fat in our study. We did find a significant increase in the more biologically active androgen, DHT, with exercise in our randomized trial. However, we also did not detect a decrease in testosterone that would be considered deleterious to men’s health. Correlations between percent body fat and estradiol, free estradiol, and 3α-Diol-G were not statistically significant.
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